Chemotherapy for Cervical Cancer
نویسندگان
چکیده
The Gynecologic Oncology Group (GOG) is a large organization with collaboration among institutions in the USA. The group has been active in many important trials involving gynecologic cancers. Until March 2011, 477 protocols were completed (82 phase III, 311 phase II, and other phase I, staging or special studies) while 50 are currently active (1). From the first (GOG 1) to the last trial (GOG 9919), many of them have generated a large body of knowledge providing answers in areas of controversy derived from retrospective studies. Others have given important information which guide the clinical practice in gynecologic cancer care worldwide. We cover in this chapter key GOG studies focusing on the role of chemotherapy for cervical, uterine, ovarian cancers, and gestational trophoblastic neoplasms.
منابع مشابه
NEOADJUVANT CHEMOTHERAPY WITH VINCRISTINE AND CISPLATIN FOLLOWED BY RADICAL HYSTERECTOMY AND PELVIC LYMPH ADENECTOMY FOR FIGO STAGE IB BULKY CERVICAL CANCER
Twenty patients with bulky (>4 cm size) FIGO stage IB cervical cancer were treated with cisplatin 50 mg/m2 and vincristine 1 mg/m2, administered intravenously at 10-day intervals for a total of 3 courses before radical hysterectomy. A complete clinical response was noted in 1 patient (5%) and partial response in 5 (25%). Fourteen patients (70%) had stable disease. There was no grade 3 toxic...
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